Stimulants vs non‑stimulants for adult ADHD?
Quick answer: Stimulants are first‑line for adult ADHD in most guidelines and often act quickly. Non‑stimulants are alternatives when stimulants are not suitable or tolerated. Decisions are individualized and consider goals, side effects, sleep, cardiovascular factors, and comorbid conditions, with follow‑up to adjust dosing.
Stimulants (methylphenidate/amphetamine classes) tend to have larger effects and rapid onset; non‑stimulants (atomoxetine, guanfacine, some antidepressants) may be preferred based on history, comorbidity, side effects, or preference.
Typical response: stimulants help many adults (often ~70–80%); non‑stimulants can be effective when stimulants are not suitable or tolerated. Onset is generally faster with stimulants and slower with non‑stimulants.
Clinicians balance benefits, risks, and patient goals; regular follow‑up adjusts the plan. Never change or combine medicines without medical advice.